Metformin 500 for slimming, danger!

Today we’re talking about a drug that’s been diverted from its original purpose: METFORMINE 500.

As we all know, trying to lose weight can be a real challenge: draconian diets that starve, yo-yo effect, lack of motivation to start physical activity or resume good eating habits… It’s understandable that for some people, the choice of a weight-loss drug is very tempting.

We have already mentioned the case of Contrave, or more recently Revia. Today, we turn our attention to METFORMINE 500, another misappropriated drug used for weight-loss purposes.

For safer weight loss safer way, choose dietary supplements recognized for their slimming effects, and above all authorized by the relevant authorities. Here’s our selection of the TOP 4 fat burners by weight-loss enthusiasts:

What is Metformin 500?

Metformin 500 is an anti-diabetic medication from the biguanide family, designed to combat hyperglycemia, i.e. high blood sugar levels. Biguanides improve sensitivity to insulin, which helps sugar penetrate cells.

Metformin 500 is usually used for diabetes without ketoacidosis, non-insulin-dependent diabetes and overweight diabetes.

More rarely, it is prescribed for some people with insulin-dependent diabetes who are also significantly overweight.

As you will have gathered, Metformin 500 is a prescription-only drug. prescription-only, to a very specific specific population. So why is it being used for weight loss? The reasons for this detour are best understood by examining the mechanism of action of Metformin 500.

Metformin 500 – Mechanism of action

For years, the mechanism of action of Metformin 500 has remained unclear to researchers.

An American team had first shown that metformin activates an enzyme called AMPK, which inhibits the genes responsible for glucose production in the liver.

But this did not fully unravel the mystery of Metformin 500’s action.

In 2010, French researchers were able to understand how metformin works in the body.

In fact, modulation of AMPK does not directly regulate glucose production by the liver.

And metformin has two modes of action, one short-term, the other long-term. Let’s summarize them.

Short-term action of metformin :

Metformin’s short-term mode of action is independent of AMPK and a gene effect.

In fact, metformin inhibits the production of hepatic glucose (i.e., glucose secreted by the liver) via an energy mechanism: a change in the functioning of mitochondria, organelles that produce energy in the form of ATP.

Metformin produces a moderate reduction in ATP production in liver cells, sufficient to reduce glucose production.

Long-term action of metformin:

In the long term, the researchers hypothesize that AMPK activation by metformin could improve hepatic steatosis, i.e. an accumulation of lipids in the liver often associated with Type 2 diabetes.

This effect would lead to improved insulin sensitivity, and prevent runaway glucose production by the liver.

(Source: The Journal of Clinical Investigation. The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Miller RA, Birnbaum MJ. J Clin Invest. 2010 Jul;120(7):2267-70. doi: 10.1172/JCI43661. Epub 2010 Jun 23).

See also our TOP 4 selection of the best detoxes :

Why is Metformin 500 prescribed for weight loss?

A priori, this medication is intended for diabetics, period.

However, losing weight can be so difficult and hopeless that some doctors nowadays don’t hesitate to use Metformin 500 to lose weight!

Metformin 500 for weight loss is increasingly being prescribed as an appetite suppressant, and pharmacists are reporting a certain type of prescription that is becoming more and more common.

“Metformin 500, one tablet a day, 850 milligrams., the perfect dose for weight loss…

And on the forums, many people testify to weight loss of up to 10 kg in just a few weeks, thanks to Metformin 500 for weight loss. And more and more people are seeking to obtain this drug without a prescription…
In fact, the reduction in insulin resistance means that the pancreas works less, while maintaining maximum efficiency. As a result, insulin levels in the blood are reduced.

Excess insulin is known to lead to fat storage. A reduction in blood insulin levels will logically lead to a reduction in fat reserves.

In this case, there’s no denying that Metformin 500 can, perhaps in some cases, promote weight loss.

The question is: at what price? After all, the list of side effects and contraindications is so long that it’s bound to dissuade anyone looking to embark on this adventure!

Metformin 500 side effects and contraindications

Contraindications :

• Pre-existing renal insufficiency, or renal insufficiency developing during treatment, contraindicates the use or continued use of metformin;
• Severe liver cell dysfunction and drunkenness are contraindications to the use of metformin.

  Alcohol intoxication is also likely to promote lactic acidosis, especially on an empty stomach.

  Lactic acidosis is a rare condition in which blood lactate levels exceed 7 mmol per liter and acidity (pH) in arterial blood is less than 7.25 mmol per liter.
  In other words, this is a particular form of acidosis (excessively high blood acidity) due to the accumulation of too much lactic acid in the blood.

  Lactic acidosis can occur in patients with diabetes treated with biguanide-containing drugs such as Glucinan, Stagid or Glucophage.

  This condition is also seen in patients with impaired renal filtration (renal failure);

• Impaired functioning of the heart pump itself, or of the respiratory system, contraindicates the use of this drug, as does a recent myocardial infarction.

Undesirable effects:

At the start of treatment:

• Nausea ;
• Vomiting;
• Abdominal pain;
• Diarrhea;
• Loss of appetite ;
• Sensation of metallic taste in the mouth;
• Reddening of the skin.

This drug sometimes exposes the patient to a sometimes serious complication: lactic acidosis.

Lactic acidosis is favored by the presence of even slight renal filtration insufficiency or severe hepatic insufficiency.

Infections, other medications, stress and anxiety are all likely to increase blood sugar levels.

Intense thirst, asthenia (severe fatigue) or a feeling of general malaise should prompt medical advice.

Precautions for use :

• Creatinine levels in the blood should be checked before treatment, and every 3 to 6 months during treatment, to verify possible renal insufficiency;
• In the event of surgery (or other causes likely to decompensate diabetes), insulin must be used;
• Diabetes can sometimes cause insensitivity to pain in the lower limbs, and more specifically in the feet.

  It can also encourage superinfection of superficial wounds, leading to deep wounds that can sometimes be serious.

  For this reason, rigorous hygiene and comfortable footwear are essential to limit these risks;

• Any rapid and significant weight change should be reported;
• If a patient has to undergo an X-ray examination requiring the administration of an intravenous contrast medium, treatment must be interrupted and resumed at least 48 hours later.

  The same applies to surgery or similar procedures.

Pregnancy and breast-feeding:

Poorly controlled diabetes is most often the cause of problems during pregnancy. Insulin replacement and reinforced medical supervision are necessary.

Should pregnancy occur after the start of treatment, it is necessary to switch to insulin.

According to current medical knowledge, metformin does not cause embryonic or fetal malformation in humans.

At present, it is not known from various studies whether the drug passes into breast milk or not. Metformin is therefore contraindicated during breast-feeding.

Drug interactions:

Certain drugs can alter blood sugar levels and consequently unbalance glycemia:

• Corticoids (cortisone);
• Diuretics;
• Bronchodilator drugs used in asthma;
• Converting enzyme inhibitors.

Testimonials from Metformin 500 users

People who have used this weight-loss drug report a variety of experiences, showing that Metformin 500 for weight loss can produce all kinds of results.

Some people have lost 2kg a week on the drug, while others have seen no change at all.

Specialists continue to find this aberrant, because according to them, this drug has never made anyone lose weight.

See also our TOP 4 selection of the best appetite suppressants :

Price and guarantee

With a prescription drug, there are no guarantees, of course. Especially since Metformin 500 is not originally prescribed for weight loss!

As a prescription drug, it is partially reimbursed by social security.

Our opinion on Metformine 500 for weight loss

We remain faithful to our policy of prohibit any misuse of medication for weight-loss purposes.

Metformin 500 has too many side effects, most of them potentially serious, and is not intended for weight loss.

We recommend that anyone wishing to transform their body adopt a reasoned attitude that is beneficial to their health.