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Metformin 500 for slimming, danger!

Metformine Produit non validéToday we’re talking about a drug that’s been diverted from its original purpose: METFORMINE 500.

As we all know, trying to lose weight can be a real challenge: draconian diets that starve, yo-yo effect, lack of motivation to start physical activity or resume good eating habits… It’s understandable that for some people, the choice of a weight-loss drug is very tempting.

We have already mentioned the case of Contrave, or more recently Revia. Today, we turn our attention to METFORMINE 500, another misappropriated drug used for weight-loss purposes.

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What is Metformin 500?

metformine500-pour-maigrirMetformin 500 is an anti-diabetic medication from the biguanide family, designed to combat hyperglycemia, i.e. high blood sugar levels. Biguanides improve sensitivity to insulin, which helps sugar penetrate cells.

Metformin 500 is usually used for diabetes without ketoacidosis, non-insulin-dependent diabetes and overweight diabetes.

More rarely, it is prescribed for some people with insulin-dependent diabetes who are also significantly overweight.

As you will have gathered, Metformin 500 is a prescription-only drug. prescription-only, to a very specific specific population. So why is it being used for weight loss? The reasons for this detour are best understood by examining the mechanism of action of Metformin 500.

Metformin 500 – Mechanism of action

For years, the mechanism of action of Metformin 500 has remained unclear to researchers.

An American team had first shown that metformin activates an enzyme called AMPK, which inhibits the genes responsible for glucose production in the liver.

But this did not fully unravel the mystery of Metformin 500’s action.

In 2010, French researchers were able to understand how metformin works in the body.

In fact, modulation of AMPK does not directly regulate glucose production by the liver.

And metformin has two modes of action, one short-term, the other long-term. Let’s summarize them.

Short-term action of metformin :

Metformin’s short-term mode of action is independent of AMPK and a gene effect.

In fact, metformin inhibits the production of hepatic glucose (i.e., glucose secreted by the liver) via an energy mechanism: a change in the functioning of mitochondria, organelles that produce energy in the form of ATP.

Metformin produces a moderate reduction in ATP production in liver cells, sufficient to reduce glucose production.

Long-term action of metformin:

In the long term, the researchers hypothesize that AMPK activation by metformin could improve hepatic steatosis, i.e. an accumulation of lipids in the liver often associated with Type 2 diabetes.

This effect would lead to improved insulin sensitivity, and prevent runaway glucose production by the liver.

(Source: The Journal of Clinical Investigation. The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Miller RA, Birnbaum MJ. J Clin Invest. 2010 Jul;120(7):2267-70. doi: 10.1172/JCI43661. Epub 2010 Jun 23).
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Why is Metformin 500 prescribed for weight loss?

A priori, this medication is intended for diabetics, period.

However, losing weight can be so difficult and hopeless that some doctors nowadays don’t hesitate to use Metformin 500 to lose weight!

Metformin 500 for weight loss is increasingly being prescribed as an appetite suppressant, and pharmacists are reporting a certain type of prescription that is becoming more and more common.

“Metformin 500, one tablet a day, 850 milligrams., the perfect dose for weight loss…

And on the forums, many people testify to weight loss of up to 10 kg in just a few weeks, thanks to Metformin 500 for weight loss. And more and more people are seeking to obtain this drug without a prescription…
In fact, the reduction in insulin resistance means that the pancreas works less, while maintaining maximum efficiency. As a result, insulin levels in the blood are reduced.

Excess insulin is known to lead to fat storage. A reduction in blood insulin levels will logically lead to a reduction in fat reserves.

In this case, there’s no denying that Metformin 500 can, perhaps in some cases, promote weight loss.

The question is: at what price? After all, the list of side effects and contraindications is so long that it’s bound to dissuade anyone looking to embark on this adventure!

Metformin 500 side effects and contraindications

Contraindications :

  • Pre-existing renal insufficiency, or renal insufficiency developing during treatment, contraindicates the use or continued use of metformin;
  • Severe liver cell dysfunction and drunkenness are contraindications to the use of metformin.

    Alcohol intoxication is also likely to promote lactic acidosis, especially on an empty stomach.

    Lactic acidosis is a rare condition in which blood lactate levels exceed 7 mmol per liter and acidity (pH) in arterial blood is less than 7.25 mmol per liter.
    Danger detrournement medicamentIn other words, this is a particular form of acidosis (excessively high blood acidity) due to the accumulation of too much lactic acid in the blood.

    Lactic acidosis can occur in patients with diabetes treated with biguanide-containing drugs such as Glucinan, Stagid or Glucophage.

    This condition is also seen in patients with impaired renal filtration (renal failure);

  • Impaired functioning of the heart pump itself, or of the respiratory system, contraindicates the use of this drug, as does a recent myocardial infarction.

Undesirable effects:

At the start of treatment:

  • Nausea ;
  • Vomiting;
  • Abdominal pain;
  • Diarrhea;
  • Loss of appetite ;
  • Sensation of metallic taste in the mouth;
  • Reddening of the skin.

This drug sometimes exposes the patient to a sometimes serious complication: lactic acidosis.

Lactic acidosis is favored by the presence of even slight renal filtration insufficiency or severe hepatic insufficiency.

Infections, other medications, stress and anxiety are all likely to increase blood sugar levels.

Intense thirst, asthenia (severe fatigue) or a feeling of general malaise should prompt medical advice.

Precautions for use :

  • Creatinine levels in the blood should be checked before treatment, and every 3 to 6 months during treatment, to verify possible renal insufficiency;
  • In the event of surgery (or other causes likely to decompensate diabetes), insulin must be used;
  • Diabetes can sometimes cause insensitivity to pain in the lower limbs, and more specifically in the feet.

    It can also encourage superinfection of superficial wounds, leading to deep wounds that can sometimes be serious.

    For this reason, rigorous hygiene and comfortable footwear are essential to limit these risks;

  • Any rapid and significant weight change should be reported;
  • If a patient has to undergo an X-ray examination requiring the administration of an intravenous contrast medium, treatment must be interrupted and resumed at least 48 hours later.

    The same applies to surgery or similar procedures.

Pregnancy and breast-feeding:

Poorly controlled diabetes is most often the cause of problems during pregnancy. Insulin replacement and reinforced medical supervision are necessary.

Should pregnancy occur after the start of treatment, it is necessary to switch to insulin.

According to current medical knowledge, metformin does not cause embryonic or fetal malformation in humans.

At present, it is not known from various studies whether the drug passes into breast milk or not. Metformin is therefore contraindicated during breast-feeding.

Drug interactions:

Certain drugs can alter blood sugar levels and consequently unbalance glycemia:

  • Corticoids (cortisone);
  • Diuretics;
  • Bronchodilator drugs used in asthma;
  • Converting enzyme inhibitors.

Testimonials from Metformin 500 users

People who have used this weight-loss drug report a variety of experiences, showing that Metformin 500 for weight loss can produce all kinds of results.

Some people have lost 2kg a week on the drug, while others have seen no change at all.

Specialists continue to find this aberrant, because according to them, this drug has never made anyone lose weight.

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Price and guarantee

With a prescription drug, there are no guarantees, of course. Especially since Metformin 500 is not originally prescribed for weight loss!

As a prescription drug, it is partially reimbursed by social security.

Our opinion on Metformine 500 for weight loss

We remain faithful to our policy of prohibit any misuse of medication for weight-loss purposes.

Metformin 500 has too many side effects, most of them potentially serious, and is not intended for weight loss.

We recommend that anyone wishing to transform their body adopt a reasoned attitude that is beneficial to their health.

Leave a Comment


  • Christine

    Already perceived as pre-diabetic, I suffer from “metabolic syndrome”. My last blood sugar level was 1.15 and a glycated hemoglobin test showed 7?

    My doctor has me take 1000mg a day of metformin (which I tolerate well). I have moderate renal insufficiency (GFR 45), and a salt-free diet for 1 year has raised my GFR to 58.

    I’m very overweight (a danger as much as diabetes!), and for the moment I’m not budging (1? months of treatment at present). I wonder whether I’ll be one of the lucky ones who’ve found themselves lighter and healthier?

  • Solimane

    Hi my father weighs about 90 kg uses glucophage 500 mg but his rate is always high I ask you and what in can change it by metformin.merci de m’informerr

  • Gwendoline

    Hello I started metformin 500 yesterday morning. I weighed myself yesterday and today. I’ve already lost 400 grams. I don’t eat in the morning or in the evening, just at noon. We’ll see if it continues like this.

  • vivier raymond

    Hello. OH surprise? I am a type 2 diabetic, my blood sugar level is between 0.90 and 1.28, my daily intake is 1 tablet on the advice of my doctor.
    Tablets morning, noon and evening, i.e. 3 a day, my weight is 68 kilos for 1.65 m. Why take Metformin 500? Thank you

    • Hélène. M

      With a glycemia of 1.28, medicine considers that it is a diabetes, even if it is a value which seems acceptable. generally the doctors advise initially a diet low in sugars to balance glycemia, but certain factors can push to a medical prescription like:
      Family history of diabetes.


      Associated hypertension.

      Metabolic syndrome.

      You have every right to ask your doctor to understand his or her reasons for putting you on treatment.

      Have a nice day.

  • lucien tremblay

    I read on the internet that the consumption of metformin to come to cut the legs rep this can happen me I want to die all at once rep thank you

    • Hélène. M

      Hello Lucien,
      Metformin is widely used to treat type 2 diabetes and brings definite benefits to these patients. On the other hand, this molecule is totally inadvisable outside its medical use and under the supervision of the attending physician, precisely to avoid unnecessary exposure to its many side effects, which can be potentially serious.

      Have a nice evening!

  • Anonymous


  • Ana- maria

    Hello. It’ s important for me to understand what happened, because I consider Metformin a precious medication with multiple benefits.

    Over the last 4-5 years, I have had a significant and disturbing weight gain. Having decided to make a change, I have taken the following (since I can’t decide which one worked) metformin: gradually up to 3000 mg. Dhea 50 mg. femostone (estrogen and progesterone substitute, as I am 55) sibuthramine 15 mg. In 1 year I lost 25 kg. I look great, no celulite, no sagging skin. At one point, suddenly, the metformin principle (combined with red wine, which I’ve always drunk in large quantities) made me extremely dizzy, with nausea, vomiting and deep perspiration, which lasted for days on end. As soon as I tried metformin again, the symptoms returned. Now, after 4 attempts, it’s clear to me: without having changed anything in the principle of other medications or wine (a little too much!), it’s Ka metformin that, after 18 months with no undesirable effects, was producing violent vertigo (couldn’t stand up), nausea, vomiting (I had to resort to intravenous hydration for days)? how is this possible? Could I go back on metformin in a month or so? Am I getting fat again? I’ve always been fat? thin before this episoade around 50… Thank you for your suggestions

    • Hélène Marfak

      Hello Ana-maria,
      You can find all the information you need about Metformin on our website, as well as about the dangers of using it outside its medical indication.

      As you are taking several products, combined with alcohol (which is totally contraindicated with Metformin!), it’s up to your doctor to advise you on the best course of action to take to get back to your former weight. It might be a good idea to stop all these mixtures and start again from a healthier base, by referring you to your GP.

      Have a nice day

  • Anonymous


  • coco

    Hello, I started taking metformin sandoz 850 a week ago. My doctor prescribed it to boost my metabolism, which is very slow. I am not diabetic, but following a blood test my blood sugar level was found to be 101, not alarming as my doctor said, but I need to lose weight at all costs! So I how much walking (3km /day minimum) with this drug….my question is it really effective? Or does it depend on each person?

    • Corinne Kepler

      Hello Coco,
      Metfotmine is not a dietary supplement but a drug prescribed for overweight diabetics. I hope your doctor knows what he’s doing, because he’s the one who can decide whether such treatment is appropriate.

      Keep an eye on your health!

      All the best.

  • Anonymous


  • ragaigne

    hello, I haven’t drunk alcohol for 2 months, although I used to drink rum regularly, my brother drinks more than I do and his addictologist has prescribed REVIA which he has been taking for 3 weeks and has lost 7 kgs, being overweight, I have been prescribed REVIA under cover of my alcohol problem and I would like to know if I take it, will I lose weight? I’m in good health and all these side effects scare me a bit. I’d like your opinion, if I could lose just a few kilos without endangering my life, I’d be happy.


    BERBERINE is said to have the same action as METFORMINE but without the effects because it’s natural? What do you think?

    Merci de me répondre.

    • Cédric Pastori

      Anny, hello,
      Thank you for your message. From the information available on the net, it seems that berberine has the same mechanism of action on AMPK (Adenosine Monophosphate activated Protein Kinase). I believe that as long as it comes from a natural source such as barberry, there should be no risks associated with its consumption. However, I strongly recommend that you seek medical advice: health is no laughing matter!

      All the best!

  • audrey


    I am pre-diabetic and my doctor prescribed Metformin 500 1/day?

    Basically it wasn’t to lose weight but to regulate my blood sugar level… However, over 6 weeks, I’ve lost 5 kilos (which I’m happy about????)
    It’s sad to put one’s health at risk for a few kilos… if I could choose, I’d rather get my 5 kilos back but have a perfect blood test….


    I’ve been taking Metformin 500 for 5 years 1 in the morning 1 in the evening, it hasn’t made me lose any weight at all, only a Mediterranean diet has helped me lose weight,

    • Cédric

      Has this medication been prescribed to you by a doctor?

      Best regards,


    Hello, what is the status of SAXENDA thank you

    • Corinne Kepler

      We have already answered you in a previous comment.

      • jean paul

        me i am sick with this medoc metformine sandoz 500mg so i stopped

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