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Tesofensine, the pill to lose 10 kg in 6 months!

gelules-tesofensineTESOFENSINE is an experimental drug twice as effective as any other weight-loss drug on the market.

This molecule is still in the development stage, but the results of clinical tests are already very encouraging.

Let’s take a look at this substance with astonishing slimming powers.

What is Tesofensine?

Tesofensine is a monoamine inhibitor targeting obesity and type 2 diabetes. It is a prescription-only drug.

Initially, this molecule was being tested for the treatment of Alzheimer’s and Parkinson’s diseases. The results of studies on these two diseases were inconclusive, but researchers were able to observe significant weight loss in patients treated with tesofensine.

The molecule has thus changed its target, and since then has been the subject of serious studies to delimit its true effect on obesity and overweight. Researchers are already very ambitious, talking of a product twice as powerful as the best slimming pill known to date.

Who manufactures Tesofensine?

Tesofensine was first developed by NeuroSearch, a laboratory specializing in the research and development of substances to treat nervous system disorders. When the focus of research shifted to the treatment of obesity, NeuroSearch handed over to the Danish company Saniona.

Saniona develops drugs to treat a range of disorders, including central nervous system disorders, autoimmune diseases and pain.

In terms of transparency and trust, we have nothing to complain about. Saniona is a major pharmaceutical laboratory with an impeccable track record, and is the originator of innovative drug substances.

How does Tesofensine work?

Tesofensine works by inhibiting serotonin, noradrenalin and dopamine. A member of the phenyltropane family, it acts as an appetite suppressant.

Tesofensine also appears to have the ability to increase basal metabolism. This means that this molecule will enable you to burn more calories and fat, even at rest.

Valid Science Tesofensine

What does science have to say about tesofensine?

To begin with, it’s important to know that studies on this molecule are carried out on human subjects. This is a very good thing, because it means that the results are directly usable. Usually, experimental studies are tested on rodents, and the process of moving on to testing on humans can be very lengthy; sometimes it doesn’t even take place at all.

As already mentioned, this substance was first studied for the treatment of Parkinson’s and Alzheimer’s disease. In phase 2 of clinical trials for the treatment of these 2 diseases, a clear side effect was observed in obese patients: a significant reduction in weight. Over a 6-month treatment period, the weight-loss results recorded were far more significant than with any other weight-loss drug on the market to date.

Here are the losses observed over 6 months, with different dosages of tesofensine applied to three different groups:

  • Weight loss of 12.8 kg at 1 mg daily;
  • Weight loss of 11.3 kg with 0.5 mg daily;
  • Weight gain of 6.7 kg with a daily dose of 0.25 mg.

On the other hand, people taking a placebo in the same experiment lost an average of 2.2 kg during the 6 months of treatment.

With weight losses of 10.6%, 9.2% and 4.5% of body weight respectively in the 3 respective groups, tesofensine was found to be 2 times more effective than all currently FDA-approved drugs for treating obesity.

Another complementary study was carried out on 140 subjects. Subjects were treated with 0.5 to 1 mg of tesofensine daily for 24 weeks, followed by a 3-month break, and then resumed treatment for a further 24 weeks. Results showed an average weight loss of 13-14 kg at the end of the full 48-week treatment period.

(Source: NCBI. PET Centre, Department of Medical Imaging, Uppsala University Hospital, Uppsala, Sweden. Department of Pharmaceuticals Sciences, Uppsala University, Uppsala, Sweden. Neurosearch A/S, Pederstrupvej 93, DK-2750 Ballerup, Denmark. Department of Biochemistry and Organic Chemistry, Uppsala University, Uppsala, Sweden. Appel L., Bergström M., Buus Lassen J., Langström B. Eur Neuropsychopharmacol. 2014 Feb; 24(2): 251-61. doi :10.1016/j;euroneuro.2013.10.007. Epub 2013 Oct 22).

And finally, here’s a study that concludes that tesofensine’s effect on body weight loss is twice as effective as any weight-loss drug known to date.

(Source: The Lancet. Volume 372, n°9653, p1906-1913, November 29, 2008. Prof. Arne Astrup, MD, Prof. Sten Madsbad, MD, Leif Breum, MD, Thomas J Jensen, MD, Jens Peter Kroustrup, MD, Thomas Meinert Larsenn PhD. doi : 10.1016/s140-6736(08)61525-1).

Side effects Contraindications of Tesofensine

During the course of tests, researchers noted that tesofensine caused an increase in heart rate and blood pressure in volunteer subjects.

In order to eliminate these undesirable effects and improve its efficacy over time, Saniona laboratories decided to carry out experimental research on the combination of tesofensine with another substance, Metoprolol, a combination which is supposed to cancel out the side effects observed.

To find out more, here’s a very detailed article on this substance :
(Source: Medline Plus. US National Library of Medicine. American Society of Health-System Pharmacists, Inc. Disclaimer).

Some people who took part in the test of this new association reported some common inconveniences such as: dry mouth, headaches, nausea, insomnia, diarrhea or constipation. However, these inconveniences appear to be minor and do not affect all those tested.

Where buy Tesofensine?

Tesofensine is a weight-loss drug prescribed by a doctor, not an over-the-counter dietary supplement.

Given its nature, tesofensine will only be available in pharmacies, and only on presentation of a doctor’s prescription.

The marketing date for this slimming pill remains undetermined. In France, the initially announced marketing date for tesofensine was 2015, or 2016 at the latest.

Tesofensine, the New Miracle?

According to the initial results of studies carried out, tesofensine appears to be a very promising substance for weight loss, but also for the treatment of type 2 diabetes. Since tesofensine is a drug, a valid prescription from a doctor is essential for weight loss. This is a guarantee of proper use and safety for users, and a good thing too.

We are awaiting the results of trials currently in development, working on the combination of metoprotol and tesofensine, to find out when this drug will be marketed.

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